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KMID : 0355519900140010007
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Korean Journal of Oral Biology
1990 Volume.14 No. 1 p.7 ~ p.18
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EFFECTS OF CAPSAICIN, PARADOL AND SHOGAOL ON THE NEURAL ACTIVITY AND SUBSTANCE P RELEASE IN TRIGEMINAL SENSORY NUCLEUS
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Abstract
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The purpose of this investigation was to determine the relative analgesic effectiveness of paradol and shogaol compared with capsaicin, and effects of capsaicinoids on substance P of trigeminal spinal sensory nucleus.
Under anesthesia, anterior belly of digastric muscle was exposed and a pair of electrodes was inserted to record the electromyograms. Noxious electrical stimulus was applied to oral mucosa around the mental foramen. Inferior alveolar nerves (IAN) and saphenous nerves were carefully exposed for application of vehicle and drugs to evaluate the effects on digastric EMG (dEMG) and neural conduction, and caudal part of brainstem was exposed to determine the substance P. Vehicle and 1.5% of capsaicin, paradol and shogaol were applied to IAN and saphenous nerves for 30 minutes, respectively. EMGs of digastric muscle evoked by noxious electrical stimulus were recorded before application of drugs or vehicle, immediately after removal and washing of drugs and at 30 minutes after washing. To examine the effects of the peripheral stimulation on the action potential, stimulating electrodes were placed on the peripheral side of drugs application site and recording electrodes were on the proximal side. Substance P of trigeminal spinal sensory nucleus was collected by push-pull perfusion technique and determined by radioimmunoassay. Capsaicin application on IAN could not influence on dEMG, but paradol and shogaol decrease the amplitude of dEMG. Capsaicin applied locally to nerve decreased amplitude and conduction velocity of only C-fiber, while paradol and shogaol inhibited the neural conduction of C-fiber and A5-fiber. Substance P in the trigeminal spinal nucleus was reduced by capsaicin but not by paradol and shogaol.
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